±Antisocial Personality Disorder (ASP), particularly psychopathy as its extraordinary structure, has incited dread and energy more than a great many years. Merciless viciousness associated with the disorder has enlivened researchers, too. The bounty of research results concerning the study of antisocial personality disorder, the misuse of substance, heritability, and treatment mediations is part of my research. Antisocial disorder can be caused from childhood delinquent, criminalized behavior, because of injuries to the prefrontal cortex. Why a person with this disorder may act thoughtlessly, ruinously, and hazardously without feeling regretful when their activities hurt others? RQ: Individuals who are diagnosed with antisocial personality disorder that misuse alcohol and medication always turn into criminals or have violent behaviors, then those who doesn’t misuse alcohol and medications.